Charcot-Marie-Tooth neuropathy (CMT) is an inherited neurological disorder that affects the peripheral nervous system. This disease causes damage to the myelin sheath, the outer covering of nerves, or to the nerve fibers themselves, resulting in muscle weakness and atrophy (muscle loss). CMT is caused by genetic mutations and there are different types (eg CMT1, CMT2), each associated with different genetic changes.
CMT is a progressive disease, meaning that symptoms can get worse over time. There is no cure for the disease, but it is possible to control the symptoms with physiotherapy, orthopedic devices and some medicines.
