The F13A1 gene encodes a protein called the Factor XIII A subunit, which plays an important role in stabilizing fibrin clots. Mutations in the F13A1 gene disrupt the function of the Factor XIII protein and cause problems with the clotting process. This leads to unstable blood clots and increased bleeding. The F13A1 mutation is inherited in an autosomal recessive manner and can be homozygous or heterozygous.
