ID:
G1079
HLA B5 genetic testing of Behçet's disease
Method:
Human Leukocyte Antigens
Full name:
Genetic testing of HLA B5 Behçet's disease
Sample Type:
Sample quantity:
Sample container:
Blood
5 ml
A tube with a purple cap
The HLA-B*51 (often referred to as HLA-B5) allele is one of the genetic markers associated with Behçet's disease. Behçet's disease is a chronic and systemic vasculitis characterized mainly by mouth and genital ulcers, skin lesions and eye inflammation.
HLA-B*51 Testing and Behçet's Disease
Diagnostic Process:
Genetic Testing: PCR (Polymerase Chain Reaction) or other genetic analysis methods are used to determine the presence of the HLA-B*51 allele.
Negative Result: A negative result for the HLA-B*51 allele does not mean that Behcet's disease is not present, as this disease is also associated with other genetic and environmental factors. A negative result is not sufficient to show that the patient does not have Behçet's disease, but it does reduce the likelihood of the disease.
Positive Result: A positive result for the HLA-B 51 allele is not sufficient on its own to diagnose Behçet's disease, but the presence of this allele is a strong predictor of a patient's risk of developing Behçet's disease. About 50-80% of patients with Behçet's disease have the HLA-B 51 allele.
Mouth ulcers: Frequently recurring mouth ulcers.
Genital ulcers: Painful ulcers on the genitals.
Skin lesions: Erythema nodosum, acne-like lesions.
Eye inflammation: Uveitis, retinitis.
Joint involvement: Arthralgia, arthritis.
Central nervous system involvement: Meningitis, encephalitis.
Vascular involvement: Thrombosis, aneurysm.